AV-1959D is a DNA vaccine designed to elicit antibodies to Aβ peptides without activating potentially harmful autoreactive T cells. This vaccine fuses coding sequences of three copies of Aβ1-11 to 12 T-cell-activating epitopes. They include a synthetic pan-T cell antigen, antigens derived from Tetanus toxin, and from the hepatitis B and influenza viruses. The foreign antigens function to boost antibody responses by activating memory and helper T cells.